<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019ddadd-b8fe-75ea-925b-03385a708aaf,g:84859697-2c3e-4f33-b480-67ae7b378070-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/CondensedConsolidatedBalanceSheetsUnaudited" xlink:type="simple" xlink:href="isrg-20260630.xsd#CondensedConsolidatedBalanceSheetsUnaudited"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/CondensedConsolidatedBalanceSheetsUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019ddadd-ba58-7108-8cc8-dbc431d02be2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019ddadd-ba58-7356-959c-211ca48983ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ddadd-ba58-7108-8cc8-dbc431d02be2" xlink:to="loc_us-gaap_AssetsCurrent_019ddadd-ba58-7356-959c-211ca48983ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019ddadd-ba58-7b99-90c4-17e5b1d35c7d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ddadd-ba58-7108-8cc8-dbc431d02be2" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019ddadd-ba58-7b99-90c4-17e5b1d35c7d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesNoncurrent_019ddadd-ba58-76f5-be01-bb781ffddbd6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecuritiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ddadd-ba58-7108-8cc8-dbc431d02be2" xlink:to="loc_us-gaap_MarketableSecuritiesNoncurrent_019ddadd-ba58-76f5-be01-bb781ffddbd6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_019ddadd-ba58-7b62-bb71-a3de68790c95" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ddadd-ba58-7108-8cc8-dbc431d02be2" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_019ddadd-ba58-7b62-bb71-a3de68790c95" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_IntangibleAndOtherAssets_019ddadd-ba58-7991-be66-9256fb75c69d" xlink:href="isrg-20260630.xsd#isrg_IntangibleAndOtherAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ddadd-ba58-7108-8cc8-dbc431d02be2" xlink:to="loc_isrg_IntangibleAndOtherAssets_019ddadd-ba58-7991-be66-9256fb75c69d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019ddadd-ba58-7167-9ef6-823c2edabe00" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ddadd-ba58-7108-8cc8-dbc431d02be2" xlink:to="loc_us-gaap_Goodwill_019ddadd-ba58-7167-9ef6-823c2edabe00" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019ddadd-ba58-7e6e-999b-1aac067d9206" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019ddadd-ba58-7186-bab9-dcae8a342684" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019ddadd-ba58-7e6e-999b-1aac067d9206" xlink:to="loc_us-gaap_AccountsPayableCurrent_019ddadd-ba58-7186-bab9-dcae8a342684" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019ddadd-ba58-7a96-bd70-d8a95e096b73" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019ddadd-ba58-7e6e-999b-1aac067d9206" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019ddadd-ba58-7a96-bd70-d8a95e096b73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueCurrent_019ddadd-ba58-774f-a0db-442d1f5561f8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredRevenueCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019ddadd-ba58-7e6e-999b-1aac067d9206" xlink:to="loc_us-gaap_DeferredRevenueCurrent_019ddadd-ba58-774f-a0db-442d1f5561f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019ddadd-ba58-74c1-8f43-2f8e810e8b4c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019ddadd-ba58-7e6e-999b-1aac067d9206" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_019ddadd-ba58-74c1-8f43-2f8e810e8b4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019ddadd-ba58-711c-950a-ff034e6bddd8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019ddadd-ba58-7c51-9a57-2faee3e1f4fd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019ddadd-ba58-711c-950a-ff034e6bddd8" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019ddadd-ba58-7c51-9a57-2faee3e1f4fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_019ddadd-ba58-7fe0-9769-b4aac26ee33c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019ddadd-ba58-711c-950a-ff034e6bddd8" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_019ddadd-ba58-7fe0-9769-b4aac26ee33c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019ddadd-ba58-7170-8f84-7f55b525fd16" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019ddadd-ba58-711c-950a-ff034e6bddd8" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019ddadd-ba58-7170-8f84-7f55b525fd16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019ddadd-ba58-780f-a0a4-91fd16daddd2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019ddadd-ba58-711c-950a-ff034e6bddd8" xlink:to="loc_us-gaap_InventoryNet_019ddadd-ba58-780f-a0a4-91fd16daddd2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019ddadd-ba58-7b8a-830d-36b23fe83426" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019ddadd-ba58-711c-950a-ff034e6bddd8" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019ddadd-ba58-7b8a-830d-36b23fe83426" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019ddadd-ba58-7fe4-a117-fe1383862ad1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019ddadd-ba58-78c0-bed6-ceacefb60c85" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019ddadd-ba58-7fe4-a117-fe1383862ad1" xlink:to="loc_us-gaap_StockholdersEquity_019ddadd-ba58-78c0-bed6-ceacefb60c85" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterest_019ddadd-ba58-7fcf-bd54-cf487c660ea9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MinorityInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019ddadd-ba58-7fe4-a117-fe1383862ad1" xlink:to="loc_us-gaap_MinorityInterest_019ddadd-ba58-7fcf-bd54-cf487c660ea9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019ddadd-ba58-7c2b-aa1b-7ced9503c009" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019ddadd-ba58-7180-b684-2005ccdb3dc2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019ddadd-ba58-7c2b-aa1b-7ced9503c009" xlink:to="loc_us-gaap_Liabilities_019ddadd-ba58-7180-b684-2005ccdb3dc2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019ddadd-ba58-784f-a352-579ad79add30" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019ddadd-ba58-7c2b-aa1b-7ced9503c009" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019ddadd-ba58-784f-a352-579ad79add30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019ddadd-ba58-70a3-ac0e-be083e5a38b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019ddadd-ba58-7c2b-aa1b-7ced9503c009" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019ddadd-ba58-70a3-ac0e-be083e5a38b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019ddadd-ba58-7bc1-b0ac-c66cf6082508" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019ddadd-ba58-7926-adc8-68ee727423a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019ddadd-ba58-7bc1-b0ac-c66cf6082508" xlink:to="loc_us-gaap_PreferredStockValue_019ddadd-ba58-7926-adc8-68ee727423a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019ddadd-ba58-7f9a-9d7f-b2e56b0d9c44" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019ddadd-ba58-7bc1-b0ac-c66cf6082508" xlink:to="loc_us-gaap_CommonStockValue_019ddadd-ba58-7f9a-9d7f-b2e56b0d9c44" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019ddadd-ba58-72ef-afc2-a65f5ca67415" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019ddadd-ba58-7bc1-b0ac-c66cf6082508" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019ddadd-ba58-72ef-afc2-a65f5ca67415" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019ddadd-ba58-7d3d-a5aa-eb5e51a3f791" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019ddadd-ba58-7bc1-b0ac-c66cf6082508" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019ddadd-ba58-7d3d-a5aa-eb5e51a3f791" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019ddadd-ba58-7df0-8d75-314741a9fae5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019ddadd-ba58-7bc1-b0ac-c66cf6082508" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019ddadd-ba58-7df0-8d75-314741a9fae5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019ddadd-ba58-7b10-8d6d-632c9e413e76" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019ddadd-ba58-7d52-b027-fae03472740a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019ddadd-ba58-7b10-8d6d-632c9e413e76" xlink:to="loc_us-gaap_LiabilitiesCurrent_019ddadd-ba58-7d52-b027-fae03472740a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_019ddadd-ba58-7513-a16b-5447f84ff29b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019ddadd-ba58-7b10-8d6d-632c9e413e76" xlink:to="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_019ddadd-ba58-7513-a16b-5447f84ff29b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/CondensedConsolidatedStatementsofComprehensiveIncomeUnaudited" xlink:type="simple" xlink:href="isrg-20260630.xsd#CondensedConsolidatedStatementsofComprehensiveIncomeUnaudited"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/CondensedConsolidatedStatementsofComprehensiveIncomeUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019ddadd-ba58-7f41-bddd-ea2e7873c736" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019ddadd-ba58-7b98-a158-b1aa35d940eb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019ddadd-ba58-7f41-bddd-ea2e7873c736" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019ddadd-ba58-7b98-a158-b1aa35d940eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_019ddadd-ba58-75de-9cea-9c4ad785b0a8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019ddadd-ba58-7f41-bddd-ea2e7873c736" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_019ddadd-ba58-75de-9cea-9c4ad785b0a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019ddadd-ba58-7e79-84ba-17c874c1bb35" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019ddadd-ba58-7a5f-9dc5-13d855b1749f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019ddadd-ba58-7e79-84ba-17c874c1bb35" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019ddadd-ba58-7a5f-9dc5-13d855b1749f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019ddadd-ba58-7617-868e-5fe69e8694ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019ddadd-ba58-7e79-84ba-17c874c1bb35" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019ddadd-ba58-7617-868e-5fe69e8694ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019ddadd-ba58-7d72-98f5-68b186619b88" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019ddadd-ba58-78a4-925e-21d11d78a3b6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019ddadd-ba58-7d72-98f5-68b186619b88" xlink:to="loc_us-gaap_GrossProfit_019ddadd-ba58-78a4-925e-21d11d78a3b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019ddadd-ba58-7620-936d-7fa807428d5f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019ddadd-ba58-7d72-98f5-68b186619b88" xlink:to="loc_us-gaap_OperatingExpenses_019ddadd-ba58-7620-936d-7fa807428d5f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019ddadd-ba58-7ca6-a805-41d505746463" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019ddadd-ba58-7d9a-ace9-1348be54506e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019ddadd-ba58-7ca6-a805-41d505746463" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019ddadd-ba58-7d9a-ace9-1348be54506e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019ddadd-ba58-7b61-9cd2-d2c2a27485eb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019ddadd-ba58-7ca6-a805-41d505746463" xlink:to="loc_us-gaap_OperatingIncomeLoss_019ddadd-ba58-7b61-9cd2-d2c2a27485eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019ddadd-ba58-7e20-880d-c7786da32958" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019ddadd-ba58-7aba-8e1b-f8d31d39abce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_019ddadd-ba58-7e20-880d-c7786da32958" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019ddadd-ba58-7aba-8e1b-f8d31d39abce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019ddadd-ba58-7903-8dc4-6e78df722d1e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_019ddadd-ba58-7e20-880d-c7786da32958" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019ddadd-ba58-7903-8dc4-6e78df722d1e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019ddadd-ba58-7a18-998b-cfc65ee6df78" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019ddadd-ba58-7779-86d6-190ce9451660" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019ddadd-ba58-7a18-998b-cfc65ee6df78" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019ddadd-ba58-7779-86d6-190ce9451660" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019ddadd-ba58-7ed2-bfd9-cdc7fc33a0ff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019ddadd-ba58-7a18-998b-cfc65ee6df78" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019ddadd-ba58-7ed2-bfd9-cdc7fc33a0ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019ddadd-ba58-730f-887a-36edff2ca95c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019ddadd-ba58-7999-b139-6c9a1186c6a5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019ddadd-ba58-730f-887a-36edff2ca95c" xlink:to="loc_us-gaap_ProfitLoss_019ddadd-ba58-7999-b139-6c9a1186c6a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019ddadd-ba58-70fb-80e6-9710f523f2a8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019ddadd-ba58-730f-887a-36edff2ca95c" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019ddadd-ba58-70fb-80e6-9710f523f2a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019ddadd-ba58-7a09-8a12-b6915f4f4263" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019ddadd-ba58-7995-9889-c9f36cfda309" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019ddadd-ba58-7a09-8a12-b6915f4f4263" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019ddadd-ba58-7995-9889-c9f36cfda309" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019ddadd-ba58-77cd-b1c5-b503a43bf2b0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019ddadd-ba58-7a09-8a12-b6915f4f4263" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019ddadd-ba58-77cd-b1c5-b503a43bf2b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019ddadd-ba58-7c0e-9d33-bcc911ec7fcf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019ddadd-ba58-7a09-8a12-b6915f4f4263" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019ddadd-ba58-7c0e-9d33-bcc911ec7fcf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_019ddadd-ba58-7553-8ef6-4aeae2b95500" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019ddadd-ba58-7a09-8a12-b6915f4f4263" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_019ddadd-ba58-7553-8ef6-4aeae2b95500" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019ddadd-ba58-745c-8ee9-e3792e0e8578" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_019ddadd-ba58-788d-8b87-37a7697cbf8b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019ddadd-ba58-745c-8ee9-e3792e0e8578" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_019ddadd-ba58-788d-8b87-37a7697cbf8b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019ddadd-ba58-717b-b9f5-799e1a930fdf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019ddadd-ba58-745c-8ee9-e3792e0e8578" xlink:to="loc_us-gaap_ProfitLoss_019ddadd-ba58-717b-b9f5-799e1a930fdf" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/CondensedConsolidatedStatementsofCashFlowsUnaudited" xlink:type="simple" xlink:href="isrg-20260630.xsd#CondensedConsolidatedStatementsofCashFlowsUnaudited"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/CondensedConsolidatedStatementsofCashFlowsUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ddadd-ba58-7794-ba74-ca2abf266f0a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019ddadd-ba58-7d24-859a-0ae4176e16ea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ddadd-ba58-7794-ba74-ca2abf266f0a" xlink:to="loc_us-gaap_ProfitLoss_019ddadd-ba58-7d24-859a-0ae4176e16ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_DepreciationandGainLossonDispositionofPropertyPlantEquipment_019ddadd-ba58-70c2-9c3e-bc5347f41b67" xlink:href="isrg-20260630.xsd#isrg_DepreciationandGainLossonDispositionofPropertyPlantEquipment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ddadd-ba58-7794-ba74-ca2abf266f0a" xlink:to="loc_isrg_DepreciationandGainLossonDispositionofPropertyPlantEquipment_019ddadd-ba58-70c2-9c3e-bc5347f41b67" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_AmortizationOfIntangibleAssetsContractAcquisitionAndOtherAssets_019ddadd-ba58-7dde-8262-b7fa90cb132e" xlink:href="isrg-20260630.xsd#isrg_AmortizationOfIntangibleAssetsContractAcquisitionAndOtherAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ddadd-ba58-7794-ba74-ca2abf266f0a" xlink:to="loc_isrg_AmortizationOfIntangibleAssetsContractAcquisitionAndOtherAssets_019ddadd-ba58-7dde-8262-b7fa90cb132e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_019ddadd-ba58-7415-a111-6591f3eafe37" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ddadd-ba58-7794-ba74-ca2abf266f0a" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_019ddadd-ba58-7415-a111-6591f3eafe37" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_019ddadd-ba58-739c-be42-e942370ec817" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ddadd-ba58-7794-ba74-ca2abf266f0a" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_019ddadd-ba58-739c-be42-e942370ec817" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019ddadd-ba58-7a09-bf56-c76070de41a1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ddadd-ba58-7794-ba74-ca2abf266f0a" xlink:to="loc_us-gaap_ShareBasedCompensation_019ddadd-ba58-7a09-bf56-c76070de41a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019ddadd-ba58-7303-ab1d-176fdfe382c7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ddadd-ba58-7794-ba74-ca2abf266f0a" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019ddadd-ba58-7303-ab1d-176fdfe382c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019ddadd-ba58-70fd-a020-b51955d2900a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ddadd-ba58-7794-ba74-ca2abf266f0a" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019ddadd-ba58-70fd-a020-b51955d2900a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019ddadd-ba58-70cc-99fd-323f736d03d9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ddadd-ba58-7794-ba74-ca2abf266f0a" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019ddadd-ba58-70cc-99fd-323f736d03d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019ddadd-ba58-74f6-811f-d82d3781a80c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ddadd-ba58-7794-ba74-ca2abf266f0a" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019ddadd-ba58-74f6-811f-d82d3781a80c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_019ddadd-ba58-7258-9cb7-12c79ab88b03" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ddadd-ba58-7794-ba74-ca2abf266f0a" xlink:to="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_019ddadd-ba58-7258-9cb7-12c79ab88b03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_019ddadd-ba58-7f4f-8cbc-9704bb936a42" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ddadd-ba58-7794-ba74-ca2abf266f0a" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_019ddadd-ba58-7f4f-8cbc-9704bb936a42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_019ddadd-ba58-70bd-ad15-7b500497290f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ddadd-ba58-7794-ba74-ca2abf266f0a" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_019ddadd-ba58-70bd-ad15-7b500497290f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_019ddadd-ba58-7174-baa4-500bd987d20a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnSaleOfBusiness"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ddadd-ba58-7794-ba74-ca2abf266f0a" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_019ddadd-ba58-7174-baa4-500bd987d20a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ddadd-ba58-7fb3-81ec-878eaac4460a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019ddadd-ba58-792e-84d2-3c1d24d6bdff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ddadd-ba58-7fb3-81ec-878eaac4460a" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019ddadd-ba58-792e-84d2-3c1d24d6bdff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_019f7042-d3b8-7cf8-874e-0a602a222721" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ddadd-ba58-7fb3-81ec-878eaac4460a" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_019f7042-d3b8-7cf8-874e-0a602a222721" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_019ddadd-ba58-74c9-a5f3-59ffc3950e7c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ddadd-ba58-7fb3-81ec-878eaac4460a" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_019ddadd-ba58-74c9-a5f3-59ffc3950e7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_019ddadd-ba58-7d47-a9f3-5065534f45fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireProductiveAssets"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ddadd-ba58-7fb3-81ec-878eaac4460a" xlink:to="loc_us-gaap_PaymentsToAcquireProductiveAssets_019ddadd-ba58-7d47-a9f3-5065534f45fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019ddadd-ba58-79db-bdc0-c29da7d7656d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ddadd-ba58-7fb3-81ec-878eaac4460a" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019ddadd-ba58-79db-bdc0-c29da7d7656d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfOtherProductiveAssets_019ddadd-ba58-7581-885f-3bbf6984f69a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleOfOtherProductiveAssets"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ddadd-ba58-7fb3-81ec-878eaac4460a" xlink:to="loc_us-gaap_ProceedsFromSaleOfOtherProductiveAssets_019ddadd-ba58-7581-885f-3bbf6984f69a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019ddadd-ba58-793d-b9b0-5c7439f2532f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ddadd-ba58-7d13-b1ee-fedc0d2b3758" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019ddadd-ba58-793d-b9b0-5c7439f2532f" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ddadd-ba58-7d13-b1ee-fedc0d2b3758" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019ddadd-ba58-74ac-8609-415a0cdede54" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019ddadd-ba58-793d-b9b0-5c7439f2532f" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019ddadd-ba58-74ac-8609-415a0cdede54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ddadd-ba58-7907-a7a1-74db531b4862" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019ddadd-ba58-793d-b9b0-5c7439f2532f" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ddadd-ba58-7907-a7a1-74db531b4862" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ddadd-ba58-7908-840a-e77ab24c4ea0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019ddadd-ba58-793d-b9b0-5c7439f2532f" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019ddadd-ba58-7908-840a-e77ab24c4ea0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ddadd-ba58-7826-acef-7f59bbe086e8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_019ddadd-ba58-7d3c-9b1c-0ce447ed4ef8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ddadd-ba58-7826-acef-7f59bbe086e8" xlink:to="loc_us-gaap_ProceedsFromStockPlans_019ddadd-ba58-7d3c-9b1c-0ce447ed4ef8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019ddadd-ba58-7392-b83a-1c9f35ee62bd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ddadd-ba58-7826-acef-7f59bbe086e8" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019ddadd-ba58-7392-b83a-1c9f35ee62bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019ddadd-ba58-70ba-9c7e-c56a84f120d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ddadd-ba58-7826-acef-7f59bbe086e8" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019ddadd-ba58-70ba-9c7e-c56a84f120d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities_019f60f5-e828-7aab-84f7-1dba2796e53e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ddadd-ba58-7826-acef-7f59bbe086e8" xlink:to="loc_us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities_019f60f5-e828-7aab-84f7-1dba2796e53e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSSummaryofCashandAvailableForSaleSecuritiesDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#FINANCIALINSTRUMENTSSummaryofCashandAvailableForSaleSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSSummaryofCashandAvailableForSaleSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleFairValue_019ddadd-ba58-7392-a92f-38a5d5cf1abb" xlink:href="isrg-20260630.xsd#isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019ddadd-ba58-713d-be10-730d89025b3a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleFairValue_019ddadd-ba58-7392-a92f-38a5d5cf1abb" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019ddadd-ba58-713d-be10-730d89025b3a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019ddadd-ba58-717f-95d8-4f580767eccf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleFairValue_019ddadd-ba58-7392-a92f-38a5d5cf1abb" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019ddadd-ba58-717f-95d8-4f580767eccf" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSSummaryofContractualMaturitiesofCashEquivalentsandAvailableForSaleInvestmentsDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#FINANCIALINSTRUMENTSSummaryofContractualMaturitiesofCashEquivalentsandAvailableForSaleInvestmentsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSSummaryofContractualMaturitiesofCashEquivalentsandAvailableForSaleInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019ddadd-ba58-7218-a8ba-ed66a80a7bd8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_019ddadd-ba58-71a5-922e-140ab03e50d0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019ddadd-ba58-7218-a8ba-ed66a80a7bd8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_019ddadd-ba58-71a5-922e-140ab03e50d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_019ddadd-ba58-7d1b-816e-9f9b42124b5b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019ddadd-ba58-7218-a8ba-ed66a80a7bd8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_019ddadd-ba58-7d1b-816e-9f9b42124b5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019ddadd-ba58-7512-84cd-28b4f54cc322" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_019ddadd-ba58-7cf9-b9ed-bb34b05f4de2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019ddadd-ba58-7512-84cd-28b4f54cc322" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_019ddadd-ba58-7cf9-b9ed-bb34b05f4de2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_019ddadd-ba58-7036-b83a-1b974206e623" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019ddadd-ba58-7512-84cd-28b4f54cc322" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_019ddadd-ba58-7036-b83a-1b974206e623" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSAvailableforSaleDebtSecuritiesinaContinuousUnrealizedLossPositionDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#FINANCIALINSTRUMENTSAvailableforSaleDebtSecuritiesinaContinuousUnrealizedLossPositionDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSAvailableforSaleDebtSecuritiesinaContinuousUnrealizedLossPositionDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_019ddadd-ba58-7215-b6aa-44e502d81a9a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_019ddadd-ba58-779a-a63f-8dd6ecc215e7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_019ddadd-ba58-7215-b6aa-44e502d81a9a" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_019ddadd-ba58-779a-a63f-8dd6ecc215e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_019ddadd-ba58-79ef-99a3-797e9f47937b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_019ddadd-ba58-7215-b6aa-44e502d81a9a" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_019ddadd-ba58-79ef-99a3-797e9f47937b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_019ddadd-ba58-73db-b6f0-a163e8635064" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_019ddadd-ba58-7749-9740-b9b0c298a55f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_019ddadd-ba58-73db-b6f0-a163e8635064" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_019ddadd-ba58-7749-9740-b9b0c298a55f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_019ddadd-ba58-7cc2-8ee1-eda293a1cc73" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_019ddadd-ba58-73db-b6f0-a163e8635064" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_019ddadd-ba58-7cc2-8ee1-eda293a1cc73" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONAccountsReceivableNetDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONAccountsReceivableNetDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONAccountsReceivableNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019ddadd-bb0b-7370-805e-ea432bd23b2e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_SalesReturnsAndAllowances_019ddadd-bb0b-7285-935a-93e6ff052bac" xlink:href="isrg-20260630.xsd#isrg_SalesReturnsAndAllowances"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_019ddadd-bb0b-7370-805e-ea432bd23b2e" xlink:to="loc_isrg_SalesReturnsAndAllowances_019ddadd-bb0b-7285-935a-93e6ff052bac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_TradeAccountsReceivableCurrent_019ddadd-bb0b-714a-a953-9128d36f551d" xlink:href="isrg-20260630.xsd#isrg_TradeAccountsReceivableCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_019ddadd-bb0b-7370-805e-ea432bd23b2e" xlink:to="loc_isrg_TradeAccountsReceivableCurrent_019ddadd-bb0b-714a-a953-9128d36f551d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_UnbilledReceivablesAndOtherReceivablesCurrent_019ddadd-bb0b-75dd-86ed-0a35ad58e935" xlink:href="isrg-20260630.xsd#isrg_UnbilledReceivablesAndOtherReceivablesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_019ddadd-bb0b-7370-805e-ea432bd23b2e" xlink:to="loc_isrg_UnbilledReceivablesAndOtherReceivablesCurrent_019ddadd-bb0b-75dd-86ed-0a35ad58e935" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONInventoryDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONInventoryDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019ddadd-bb0b-7d61-a946-5c423e48e0a1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019ddadd-bb0b-7326-a5f1-6ca4118159b9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019ddadd-bb0b-7d61-a946-5c423e48e0a1" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019ddadd-bb0b-7326-a5f1-6ca4118159b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019ddadd-bb0b-7c5e-84d7-4223ad449dfb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019ddadd-bb0b-7d61-a946-5c423e48e0a1" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019ddadd-bb0b-7c5e-84d7-4223ad449dfb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019ddadd-bb0b-7504-b9a9-041bea060545" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019ddadd-bb0b-7d61-a946-5c423e48e0a1" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019ddadd-bb0b-7504-b9a9-041bea060545" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONPrepaidsandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONPrepaidsandOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONPrepaidsandOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019ddadd-bb0b-749b-be92-35253d2e7d0f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_SalesTypeLeaseNetInvestmentInLeaseCurrent_019ddadd-bb0b-7b9f-bfc6-6c6cf1608def" xlink:href="isrg-20260630.xsd#isrg_SalesTypeLeaseNetInvestmentInLeaseCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019ddadd-bb0b-749b-be92-35253d2e7d0f" xlink:to="loc_isrg_SalesTypeLeaseNetInvestmentInLeaseCurrent_019ddadd-bb0b-7b9f-bfc6-6c6cf1608def" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherPrepaidExpenseCurrent_019ddadd-bb0b-73a4-bd1b-ae97f325123d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherPrepaidExpenseCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019ddadd-bb0b-749b-be92-35253d2e7d0f" xlink:to="loc_us-gaap_OtherPrepaidExpenseCurrent_019ddadd-bb0b-73a4-bd1b-ae97f325123d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidTaxes_019ddadd-bb0b-706d-a3e2-b04440ff503f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidTaxes"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019ddadd-bb0b-749b-be92-35253d2e7d0f" xlink:to="loc_us-gaap_PrepaidTaxes_019ddadd-bb0b-706d-a3e2-b04440ff503f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONOtherAccruedLiabilitiesShorttermDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONOtherAccruedLiabilitiesShorttermDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONOtherAccruedLiabilitiesShorttermDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019ddadd-bb0b-7953-861d-5cc60861deee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019ddadd-bb0b-7d24-b45e-fad932432c73" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019ddadd-bb0b-7953-861d-5cc60861deee" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019ddadd-bb0b-7d24-b45e-fad932432c73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_AccruedConstructionLiabilitiesCurrent_019ddadd-bb0b-735c-a0b0-4e9fc53c9969" xlink:href="isrg-20260630.xsd#isrg_AccruedConstructionLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019ddadd-bb0b-7953-861d-5cc60861deee" xlink:to="loc_isrg_AccruedConstructionLiabilitiesCurrent_019ddadd-bb0b-735c-a0b0-4e9fc53c9969" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxesPayableCurrent_019ddadd-bb0b-735e-8372-160d3d6cbb79" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TaxesPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019ddadd-bb0b-7953-861d-5cc60861deee" xlink:to="loc_us-gaap_TaxesPayableCurrent_019ddadd-bb0b-735e-8372-160d3d6cbb79" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONOtherLongtermLiabilitiesDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONOtherLongtermLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONOtherLongtermLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_019ddadd-bb0b-7fc5-b35b-6fed4089b3bb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesNoncurrent_019ddadd-bb0b-708d-a1b9-8add982c1cae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedIncomeTaxesNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_019ddadd-bb0b-7fc5-b35b-6fed4089b3bb" xlink:to="loc_us-gaap_AccruedIncomeTaxesNoncurrent_019ddadd-bb0b-708d-a1b9-8add982c1cae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueNoncurrent_019ddadd-bb0b-72fb-9c14-bf755415fcd1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredRevenueNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_019ddadd-bb0b-7fc5-b35b-6fed4089b3bb" xlink:to="loc_us-gaap_DeferredRevenueNoncurrent_019ddadd-bb0b-72fb-9c14-bf755415fcd1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesNoncurrent_019ddadd-bb0b-7511-8563-653366433d64" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAccruedLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_019ddadd-bb0b-7fc5-b35b-6fed4089b3bb" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesNoncurrent_019ddadd-bb0b-7511-8563-653366433d64" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONRestrictedCashDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONRestrictedCashDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONRestrictedCashDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019ddadd-bb0b-7223-8174-38272b7c63c9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019ddadd-bb0b-7c2d-b7c9-c47a8eebc253" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019ddadd-bb0b-7223-8174-38272b7c63c9" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019ddadd-bb0b-7c2d-b7c9-c47a8eebc253" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCash_019ddadd-bb0b-71b8-9e5b-eb130d2d31e0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCash"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019ddadd-bb0b-7223-8174-38272b7c63c9" xlink:to="loc_us-gaap_RestrictedCash_019ddadd-bb0b-71b8-9e5b-eb130d2d31e0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/LEASESLeaseReceivablesDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#LEASESLeaseReceivablesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/LEASESLeaseReceivablesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_019ddadd-bb0c-7966-8fe0-029352498c0d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLease"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_SalesTypeLeaseGrossInvestmentInLease_019ddadd-bb0c-78ff-a457-a97b5032fc56" xlink:href="isrg-20260630.xsd#isrg_SalesTypeLeaseGrossInvestmentInLease"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_019ddadd-bb0c-7966-8fe0-029352498c0d" xlink:to="loc_isrg_SalesTypeLeaseGrossInvestmentInLease_019ddadd-bb0c-78ff-a457-a97b5032fc56" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_SalestypeLeaseDeferredSellingProfit_019ddadd-bb0c-77b0-95ad-f0892f42f30f" xlink:href="isrg-20260630.xsd#isrg_SalestypeLeaseDeferredSellingProfit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_019ddadd-bb0c-7966-8fe0-029352498c0d" xlink:to="loc_isrg_SalestypeLeaseDeferredSellingProfit_019ddadd-bb0c-77b0-95ad-f0892f42f30f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/LEASESScheduleofContractualMaturitiesofGrossLeaseReceivablesDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#LEASESScheduleofContractualMaturitiesofGrossLeaseReceivablesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/LEASESScheduleofContractualMaturitiesofGrossLeaseReceivablesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_019ddadd-bb0c-793b-a17d-54c8c28acd64" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedNextTwelveMonths_019ddadd-bb0c-7675-8815-60682a464f7e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_019ddadd-bb0c-793b-a17d-54c8c28acd64" xlink:to="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedNextTwelveMonths_019ddadd-bb0c-7675-8815-60682a464f7e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedFourYears_019ddadd-bb0c-733c-a765-ed675c5b8539" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedFourYears"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_019ddadd-bb0c-793b-a17d-54c8c28acd64" xlink:to="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedFourYears_019ddadd-bb0c-733c-a765-ed675c5b8539" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedTwoYears_019ddadd-bb0c-7512-a5c2-90d38f100544" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedTwoYears"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_019ddadd-bb0c-793b-a17d-54c8c28acd64" xlink:to="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedTwoYears_019ddadd-bb0c-7512-a5c2-90d38f100544" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedYearFiveAndThereafter_019ddadd-bb0c-7e9f-bbe8-ae48fe0f1cae" xlink:href="isrg-20260630.xsd#isrg_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedYearFiveAndThereafter"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_019ddadd-bb0c-793b-a17d-54c8c28acd64" xlink:to="loc_isrg_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedYearFiveAndThereafter_019ddadd-bb0c-7e9f-bbe8-ae48fe0f1cae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedRemainderOfFiscalYear_019ddadd-bb0c-7bb5-864d-b987da53e5af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedRemainderOfFiscalYear"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_019ddadd-bb0c-793b-a17d-54c8c28acd64" xlink:to="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedRemainderOfFiscalYear_019ddadd-bb0c-7bb5-864d-b987da53e5af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedThreeYears_019ddadd-bb0c-7240-9ef8-f0b90bf9ec61" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedThreeYears"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_019ddadd-bb0c-793b-a17d-54c8c28acd64" xlink:to="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedThreeYears_019ddadd-bb0c-7240-9ef8-f0b90bf9ec61" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/LEASESCreditQualityIndicatorDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#LEASESCreditQualityIndicatorDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/LEASESCreditQualityIndicatorDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_019ddadd-bb0c-7e67-bc0e-e528fcb233ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLease"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedTwoYearsBeforeLatestFiscalYear_019ddadd-bb0c-7120-bcb8-ce89635a540b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedTwoYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_019ddadd-bb0c-7e67-bc0e-e528fcb233ba" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedTwoYearsBeforeLatestFiscalYear_019ddadd-bb0c-7120-bcb8-ce89635a540b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInFiscalYearBeforeLatestFiscalYear_019ddadd-bb0c-7361-b8af-d505b6ec3f86" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInFiscalYearBeforeLatestFiscalYear"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_019ddadd-bb0c-7e67-bc0e-e528fcb233ba" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInFiscalYearBeforeLatestFiscalYear_019ddadd-bb0c-7361-b8af-d505b6ec3f86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInCurrentFiscalYear_019ddadd-bb0c-7411-b4fa-9e61922929d9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInCurrentFiscalYear"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_019ddadd-bb0c-7e67-bc0e-e528fcb233ba" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInCurrentFiscalYear_019ddadd-bb0c-7411-b4fa-9e61922929d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedThreeYearsBeforeLatestFiscalYear_019ddadd-bb0c-7e44-9fa5-be709b0071d7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedThreeYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_019ddadd-bb0c-7e67-bc0e-e528fcb233ba" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedThreeYearsBeforeLatestFiscalYear_019ddadd-bb0c-7e44-9fa5-be709b0071d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFiveOrMoreYearsBeforeLatestFiscalYear_019ddadd-bb0c-7a02-a9ae-d58f3bf716a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFiveOrMoreYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_019ddadd-bb0c-7e67-bc0e-e528fcb233ba" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFiveOrMoreYearsBeforeLatestFiscalYear_019ddadd-bb0c-7a02-a9ae-d58f3bf716a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFourYearsBeforeLatestFiscalYear_019ddadd-bb0c-7009-a6d4-3259dcee0dbe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFourYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_019ddadd-bb0c-7e67-bc0e-e528fcb233ba" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFourYearsBeforeLatestFiscalYear_019ddadd-bb0c-7009-a6d4-3259dcee0dbe" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/BUSINESSCOMBINATIONGOODWILLANDINTANGIBLEASSETSScheduleofAssetsAcquiredDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#BUSINESSCOMBINATIONGOODWILLANDINTANGIBLEASSETSScheduleofAssetsAcquiredDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/BUSINESSCOMBINATIONGOODWILLANDINTANGIBLEASSETSScheduleofAssetsAcquiredDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_isrg_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAcquiredIncludingGoodwill_019ddadd-bb0c-7ebc-a6aa-0ab07ee30163" xlink:href="isrg-20260630.xsd#isrg_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAcquiredIncludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_019ddadd-bb0c-75b8-b543-d929013c8450" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_isrg_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAcquiredIncludingGoodwill_019ddadd-bb0c-7ebc-a6aa-0ab07ee30163" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_019ddadd-bb0c-75b8-b543-d929013c8450" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_019ddadd-bb0c-7d1b-bd83-4addc11988fa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_isrg_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAcquiredIncludingGoodwill_019ddadd-bb0c-7ebc-a6aa-0ab07ee30163" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_019ddadd-bb0c-7d1b-bd83-4addc11988fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_019ddadd-bb0c-7a94-b434-72b9cc0ad5af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_isrg_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAcquiredIncludingGoodwill_019ddadd-bb0c-7ebc-a6aa-0ab07ee30163" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_019ddadd-bb0c-7a94-b434-72b9cc0ad5af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_019ddadd-bb0c-7edc-b8fe-c5c99f61eeb3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_isrg_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAcquiredIncludingGoodwill_019ddadd-bb0c-7ebc-a6aa-0ab07ee30163" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_019ddadd-bb0c-7edc-b8fe-c5c99f61eeb3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_019ddadd-bb0c-7d55-82ec-dfdd20f4697e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_isrg_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAcquiredIncludingGoodwill_019ddadd-bb0c-7ebc-a6aa-0ab07ee30163" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_019ddadd-bb0c-7d55-82ec-dfdd20f4697e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019ddadd-bb0c-77a1-b7f9-b5332a4a61af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_isrg_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAcquiredIncludingGoodwill_019ddadd-bb0c-7ebc-a6aa-0ab07ee30163" xlink:to="loc_us-gaap_Goodwill_019ddadd-bb0c-77a1-b7f9-b5332a4a61af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_019ddadd-bb0c-7573-bd55-205b6e7f4a9d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAcquiredIncludingGoodwill_019ddadd-bb0c-7e31-95b2-60e4f3e346e5" xlink:href="isrg-20260630.xsd#isrg_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAcquiredIncludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_019ddadd-bb0c-7573-bd55-205b6e7f4a9d" xlink:to="loc_isrg_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAcquiredIncludingGoodwill_019ddadd-bb0c-7e31-95b2-60e4f3e346e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019ddadd-bb0c-7b7c-b11a-155bbf9ee598" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_019ddadd-bb0c-7573-bd55-205b6e7f4a9d" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019ddadd-bb0c-7b7c-b11a-155bbf9ee598" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019ddadd-bb0c-73a2-8e76-6e7b0b8551f5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_019ddadd-bb0c-718c-9565-5ac5dad4d6ea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019ddadd-bb0c-73a2-8e76-6e7b0b8551f5" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_019ddadd-bb0c-718c-9565-5ac5dad4d6ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_019ddadd-bb0c-77a6-8688-4fd8872c3ee3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019ddadd-bb0c-73a2-8e76-6e7b0b8551f5" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_019ddadd-bb0c-77a6-8688-4fd8872c3ee3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_019ddadd-bb0c-7785-969a-9f2197b3a3b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019ddadd-bb0c-73a2-8e76-6e7b0b8551f5" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_019ddadd-bb0c-7785-969a-9f2197b3a3b5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/BUSINESSCOMBINATIONGOODWILLANDINTANGIBLEASSETSScheduleofIntangibleAssetsDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#BUSINESSCOMBINATIONGOODWILLANDINTANGIBLEASSETSScheduleofIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/BUSINESSCOMBINATIONGOODWILLANDINTANGIBLEASSETSScheduleofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019ddadd-bb0c-7e5e-a197-f6cfac5fbf8e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019ddadd-bb0c-7d05-9cbe-93282db9e25e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019ddadd-bb0c-7e5e-a197-f6cfac5fbf8e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019ddadd-bb0c-7d05-9cbe-93282db9e25e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019ddadd-bb0c-7f4d-9014-d21d63b09472" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019ddadd-bb0c-7e5e-a197-f6cfac5fbf8e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019ddadd-bb0c-7f4d-9014-d21d63b09472" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019ddadd-bb0c-78d0-ba9c-7c6ddcd681fd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019ddadd-bb0c-7bc3-a30e-925bb33a2af1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019ddadd-bb0c-78d0-ba9c-7c6ddcd681fd" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019ddadd-bb0c-7bc3-a30e-925bb33a2af1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019ddadd-bb0c-70af-9729-1a9ad51af274" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019ddadd-bb0c-78d0-ba9c-7c6ddcd681fd" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019ddadd-bb0c-70af-9729-1a9ad51af274" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019ddadd-bb0c-7f9a-a8d6-834ef3abd066" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019ddadd-bb0c-7bd2-969c-581b43f482b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019ddadd-bb0c-7f9a-a8d6-834ef3abd066" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019ddadd-bb0c-7bd2-969c-581b43f482b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019ddadd-bb0c-76d7-9a38-ba60f1c8f735" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019ddadd-bb0c-7f9a-a8d6-834ef3abd066" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019ddadd-bb0c-76d7-9a38-ba60f1c8f735" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/BUSINESSCOMBINATIONGOODWILLANDINTANGIBLEASSETSScheduleofIntangibleAssetsDetails_1" xlink:type="simple" xlink:href="isrg-20260630.xsd#BUSINESSCOMBINATIONGOODWILLANDINTANGIBLEASSETSScheduleofIntangibleAssetsDetails_1"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/BUSINESSCOMBINATIONGOODWILLANDINTANGIBLEASSETSScheduleofIntangibleAssetsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019ddadd-bb0c-7d98-9c86-068912e3d4d2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019ddadd-bb0c-7614-ba71-2184f520f567" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019ddadd-bb0c-7d98-9c86-068912e3d4d2" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019ddadd-bb0c-7614-ba71-2184f520f567" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019ddadd-bb0c-7361-ac9b-65a553125143" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019ddadd-bb0c-7d98-9c86-068912e3d4d2" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019ddadd-bb0c-7361-ac9b-65a553125143" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/BUSINESSCOMBINATIONGOODWILLANDINTANGIBLEASSETSScheduleOfEstimatedFutureAmortizationExpenseOfIntangibleAssetsDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#BUSINESSCOMBINATIONGOODWILLANDINTANGIBLEASSETSScheduleOfEstimatedFutureAmortizationExpenseOfIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/BUSINESSCOMBINATIONGOODWILLANDINTANGIBLEASSETSScheduleOfEstimatedFutureAmortizationExpenseOfIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019ddadd-bb0c-7d47-9707-d01002624883" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_019ddadd-bb0c-702a-ad21-47e6c40f6ba7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019ddadd-bb0c-7d47-9707-d01002624883" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_019ddadd-bb0c-702a-ad21-47e6c40f6ba7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019ddadd-bb0c-77ee-882b-93eeba57d2b4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019ddadd-bb0c-7d47-9707-d01002624883" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019ddadd-bb0c-77ee-882b-93eeba57d2b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019ddadd-bb0c-7757-b1c6-e21c43fd4c4c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019ddadd-bb0c-7d47-9707-d01002624883" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019ddadd-bb0c-7757-b1c6-e21c43fd4c4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_019ddadd-bb0c-78b5-8681-6a06382860a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019ddadd-bb0c-7d47-9707-d01002624883" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_019ddadd-bb0c-78b5-8681-6a06382860a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_019ddadd-bb0c-76eb-91ac-11d5a6da39d8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019ddadd-bb0c-7d47-9707-d01002624883" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_019ddadd-bb0c-76eb-91ac-11d5a6da39d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFour_019ddadd-bb0c-7343-893f-3e93226c4ab8" xlink:href="isrg-20260630.xsd#isrg_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019ddadd-bb0c-7d47-9707-d01002624883" xlink:to="loc_isrg_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFour_019ddadd-bb0c-7343-893f-3e93226c4ab8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/STOCKHOLDERSEQUITYComponentsofAccumulatedOtherComprehensiveIncomeNetofTaxDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#STOCKHOLDERSEQUITYComponentsofAccumulatedOtherComprehensiveIncomeNetofTaxDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/STOCKHOLDERSEQUITYComponentsofAccumulatedOtherComprehensiveIncomeNetofTaxDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019ddadd-bb0c-7d11-83ef-b9651309e7f5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_019ddadd-bb0c-7a35-9067-1a0f8a350235" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019ddadd-bb0c-7d11-83ef-b9651309e7f5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_019ddadd-bb0c-7a35-9067-1a0f8a350235" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_019ddadd-bb0c-7a55-a16e-98910650f516" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019ddadd-bb0c-7d11-83ef-b9651309e7f5" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_019ddadd-bb0c-7a55-a16e-98910650f516" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SHAREBASEDCOMPENSATIONStockBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#SHAREBASEDCOMPENSATIONStockBasedCompensationExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SHAREBASEDCOMPENSATIONStockBasedCompensationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_019ddadd-bb0c-7851-9497-8098b2288b21" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019ddadd-bb0c-70eb-becb-93208ef0d374" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_019ddadd-bb0c-7851-9497-8098b2288b21" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019ddadd-bb0c-70eb-becb-93208ef0d374" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_019ddadd-bb0c-7d85-9630-943630a2a1ea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_019ddadd-bb0c-7851-9497-8098b2288b21" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_019ddadd-bb0c-7d85-9630-943630a2a1ea" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/NETINCOMEPERSHAREComputationofBasicandDilutedNetIncomePerShareDetails" xlink:type="simple" xlink:href="isrg-20260630.xsd#NETINCOMEPERSHAREComputationofBasicandDilutedNetIncomePerShareDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/NETINCOMEPERSHAREComputationofBasicandDilutedNetIncomePerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019ddadd-bb0c-7d9d-8084-5d747ec8936a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019ddadd-bb0c-74dd-8551-8c9193d388b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019ddadd-bb0c-7d9d-8084-5d747ec8936a" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019ddadd-bb0c-74dd-8551-8c9193d388b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_019ddadd-bb0c-7e43-9ac7-6562374ce36f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019ddadd-bb0c-7d9d-8084-5d747ec8936a" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_019ddadd-bb0c-7e43-9ac7-6562374ce36f" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
